Sintesis dan Karakterisasi Hidroksiapatit Cangkang Rajungan dengan Variasi Suhu Kalsinasi dan Konsentasi KH2PO4 menggunakan Metode Presipitasi Sebagai Sediaan Biomaterial Implan Tulang

Novelia Gita Romadhona, Nesha Permata Syafira, Tobing Gumelar, Vita Fatichah Rizqiyah, Eva Oktavia Ningrum

Abstract


Bone implants are mostly made of non-degradable metal materials that are toxic to the body. An alternative biodegradable material being developed is Poly-L-Lactic Acid (PLLA). However, PLLA has the disadvantage of being incompatible with bone tissue. So, materials that are biodegradable and biocompatible are needed, such as hydroxyapatite, which has similarities with the minerals in bone and teeth, it suitable as an alternative biomaterial in the biomedical. This research aims to determine the effect of synthesis conditions, with calcination temperature (850, 900, 950, 1000°C) and KH2PO4 concentration (0.25, 0.5, 0.75, 1 M), on the production of hydroxyapatite using raw materials from local blue crab shells, in terms of calcium content, functional group presence, and conformity of hydroxyapatite peaks with JCPDS 09-0432. The synthesized product was characterized using XRF, which showed a relatively high calcium in crab shells of 94.89% at calcination temperature 850°C. The FTIR test results after the mixing of KH2PO4 with CaO showed the formation of hydroxyapatite functional groups, namely OH- and PO43-, in all variables. The XRD test results showed that at 850°C and KH2PO4 concentration of 0.75 M the main peak of hydroxyapatite was closest to JCPDS 09-0432, at a diffraction angle (2θ) of 31.7634.

Keywords


Blue Crab Shell; Calcination; KH2PO4; Hydroxyapatite; Precipitation

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References


Abere, Dare Victor, et al. “Mechanical and Morphological Characterization of Nano-Hydroxyapatite (NHA) for Bone Regeneration: A Mini Review.” Biomedical Engineering Advances, vol. 4, no. October, Elsevier Inc., 2022, p. 100056, doi:10.1016/j.bea.2022.100056.

Abifarin, J. K., et al. “Experimental Data on the Characterization of Hydroxyapatite Synthesized from Biowastes.” Data in Brief, vol. 26, 2019, doi:10.1016/j.dib.2019.104485.

Agbabiaka, O. G., et al. “Effect of Calcination Temperature on Hydroxyapatite Developed from Waste Poultry Eggshell.” Scientific African, vol. 8, 2020, doi:10.1016/j.sciaf.2020.e00452.

Al-Sokanee, Zeki N., et al. “The Drug Release Study of Ceftriaxone from Porous Hydroxyapatite Scaffolds.” AAPS PharmSciTech, vol. 10, no. 3, 2009, doi:10.1208/s12249-009-9265-7.

Cho, Chul Hyun, et al. “Biomaterials Used for Suture Anchors in Orthopedic Surgery.” CiOS Clinics in Orthopedic Surgery, vol. 13, no. 3, 2021, doi:10.4055/cios20317.

Chudhuri, Biswadeep, et al. “Hydroxyapatite and Hydroxyapatite-Chitosan Composite from Crab Shell.” Journal of Biomaterials and Tissue Engineering, vol. 3, no. 6, American Scientific Publishers, 2013, pp. 653–57.

García, Belkis, et al. “CoMo/Zn-Hydroxyapatites as Catalysts for the Hydrodesulfurization Reaction of Thiophene.” Indian Journal of Chemical Technology, vol. 19, no. 6, 2012.

Gomes, Joo F., et al. “An Investigation of the Synthesis Parameters of the Reaction of Hydroxyapatite Precipitation in Aqueous Media.” International Journal of Chemical Reactor Engineering, vol. 6, 2008, doi:10.2202/1542-6580.1778.

Ivankovic, H., et al. “Preparation of Highly Porous Hydroxyapatite Ceramics from Cuttlefish Bone.” Materials in Clinical Applications VII, vol. 49, 2006, doi:10.4028/www.scientific.net/ast.49.142.

Kunduru, Konda Reddy, et al. “Biodegradable Polymers: Medical Applications.” Encyclopedia of Polymer Science and Technology, 2016, doi:10.1002/0471440264.pst027.pub2.

Levingstone, Tanya. “Optimisation of Plasma Sprayed Hydroxyapatite Coatings.” Thesis, 2008.

Longo, Umile Giuseppe, et al. “Metallic versus Biodegradable Suture Anchors for Rotator Cuff Repair: A Case Control Study.” BMC Musculoskeletal Disorders, vol. 20, no. 1, 2019, doi:10.1186/s12891-019-2834-3.

Mohd Pu’ad, N. A. S., et al. “Synthesis Method of Hydroxyapatite: A Review.” Materials Today: Proceedings, vol. 29, 2019, doi:10.1016/j.matpr.2020.05.536.

Mondal, Sudip, et al. “Studies on Processing and Characterization of Hydroxyapatite Biomaterials from Different Bio Wastes.” Journal of Minerals and Materials Characterization and Engineering, vol. 11, no. 01, 2012, doi:10.4236/jmmce.2012.111005.

Ningrum, E. O., et al. “Production of Bone Implant Filaments from Blue Crab Shells (Portunus Pelagicus) in Various Synthesis Conditions and Blending Ratios of Hydroxyapatite (HAp)-Polycaprolactone (PCL).” IOP Conference Series: Earth and Environmental Science, vol. 963, no. 1, 2022, doi:10.1088/1755-1315/963/1/012021.

Ooi, C. Y., et al. “Properties of Hydroxyapatite Produced by Annealing of Bovine Bone.” Ceramics International, vol. 33, no. 7, 2007, doi:10.1016/j.ceramint.2006.04.001.

Pankaew, P., et al. “Temperature Effect on Calcium Phosphate Synthesized from Chicken Eggshells and Ammonium Phosphate.” Journal of Applied Sciences, vol. 10, no. 24, 2010, doi:10.3923/jas.2010.3337.3342.

Purnama, EF. “Pengaruh Suhu Reaksi Terhadap Derajat Kristalinitas Dan Komposisi Hidroksiapatit Dibuat Dengan Media Air Dan Cairan Tubuh Buatan (Synthetic Body Fluid).” Indonesian Journal of Materials Science, 2006.

Raya, Indah, et al. “Shynthesis and Characterizations of Calcium Hydroxyapatite Derived from Crabs Shells (Portunus Pelagicus) and Its Potency in Safeguard against to Dental Demineralizations.” International Journal of Biomaterials, vol. 2015, 2015, doi:10.1155/2015/469176.

Shan, Zhengming, et al. “Development of Degradable Magnesium-Based Metal Implants and Their Function in Promoting Bone Metabolism (A Review).” Journal of Orthopaedic Translation, vol. 36, 2022, doi:10.1016/j.jot.2022.09.013.

Taji, Lulu Sekar, et al. “Hydroxyapatite Based Material: Natural Resources, Synthesis Methods, 3D Print Filament Fabrication, and Filament Filler.” IPTEK The Journal of Engineering, vol. 8, no. 1, 2022, doi:10.12962/j23378557.v8i1.a12830.

V. Restrepo-Ramírez, et al. “Influence of the Calcination Temperature on the Crystallographic , Compositional and Morphological Properties of Natural Hydroxyapatite Obtained From.” Scientia et Technica Año XXVI, vol. 26, no. 04, 2021, pp. 525–31, doi:https://doi.org/10.22517/23447214.24888.

Wu, Shih Ching, et al. “Synthesis of Hydroxyapatite from Eggshell Powders through Ball Milling and Heat Treatment.” Journal of Asian Ceramic Societies, vol. 4, no. 1, 2016, doi:10.1016/j.jascer.2015.12.002.


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