Kecepatan Pelepasan Parasetamol dari Crosslinked Carrageenan-PVA Film: Pengaruh Rasio Carrageenan-PVA dan Waktu Pengisian (Loading)

Abstract

Carrageenan which was extracted from seaweed Eucheuma cottonii was mixed with polyvinylalcohol (PVA) and
then carrageenan-PVA was modified with crosslinking method using glutaraldehyde. The result of hydrogel
films was applied to control the drug release rate of paracetamol. The aim of this research to determine a
mathematical model that can be used to describe the events of drug release paracetamol, determine the effect of
weight ratio carrageenan-PVA (5:0, 1:0.5, 1:1, 1:2, 0:5) and the loading time of paracetamol (2 and 12 hours)
on the parameters of paracetamol release rate from carrageenan-PVA film in a buffer solution pH = 7,4. The
research include several steps, the step of making carrageenan-PVA films, crosslinking carrageenan-PVA films,
filling the film with paracetamol (Loading) and releasing test of paracetamol in a buffer solution. The
mathematical model arranged can describe the mass transfer rate of paracetamol. The weight ratio of
carrageenan-PVA greatly affect the amount of paracetamol was absorbed in the hydrogel film (Xo) and the
release rate of paracetamol in a buffer solution (kCa). The longer time of loading, paracetamol could be
adsorbed more. Paracetamol release rate was faster at loading time 12 hours compared to 2 hours except the
PVA film without carrageenan.