Pengaruh Asupan Berbagai Jenis Biji-bijian Terhadap Peningkatan Kadar Asam Urat pada Tikus Putih Jantan (Rattus norvegicus)

Dhanang Puspita, Rosiana Eva Rayanti, Yohana Ikka Maylani, Theresia Pratiwi Elingsetyo Sanubari

Abstract


Grains known as foods that contain purine. The existence of purines can cause gout patients/ hyperuricemia
increased levels of uric acid in the blood. High levels of uric acid cause gout arthritis. This study aims to
determine the increase in uric acid levels in male rats (Rattus norvegicus) by the intake of various types of
grain. Male rats per group were given intake melinjo (Gnemon gnetum), soy (Glycine max), white rice
(Oryza sativa), peanuts (Arachis hypogaea), red beans (Phaseolus vulgaris), green beans (Vigna radiata),
and BR1 (as control). Long treatment for 15 days. Calculation of uric acid levels in male rats at the start of
the day to 0, 5, 10, and 15. The measurement results showed that rats with intake a diet melinjo seeds have
elevated levels of uric acid highest is 20 mg/dl and the lowest is peanuts (7,2 mg/dl), while control is 4,2
mg/dl. The amount of uric acid content in rats with grain intake showed a high purine content. This study
concluded that contribute grain in elevated uric acid levels are highest is melinjo, rice, green beans,
soybeans, red beans, and peanuts.


Keywords


grain, hyperuricemia, male-rats, uric-acid.

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