Studi Awal Pembuatan Koloid Kromik Fosfat Bertanda Radioisotop 32P Sebagai Bahan Pembuatan Skin Patch

Wira Y. Rahman, Endang Sarmini, Herlina Herlina, Hambali Hambali, Abidin Abidin, Triyanto Triyanto, Sriyono Sriyono, Triani Widyaningrum


Keloids are skin disorders or benign tumors that are due to abnormal wound healing in the binding tissue after a trauma, inflammation, surgical wounds, or burns. Low activity radioisotopes have shown to be effective in curing or eliminating keloids on the skin. One of these radioisotopes is phosphorus-32 (32P), a beta (β-) emitter with a half-life of 14.3 days. This radioisotope can also be developed for the treatment of keloid and skin tumors. Currently, keloid is treated by a conventional method e.g. by applying the bulk of 32P radioisotope directly on keloid area and this method is considered inefficient and less secure. The purpose of this research is to obtain technology for preparing of a 32P-labeled skin patch. The first step of this research is to produce 32P-labeled chromic phosphate (Cr32PO4) colloids, through condensation involving oxidation-reduction reaction. In this step, Cr (VI) is reduced to Cr (III) to form Cr32PO4 with a particle size of <1 μm.  These particles (Cr32PO4) are to expect to distribute evenly when mixed with silicon to form skin patch which will not decompose easily.  Characterization of the prepared Cr32PO4 colloids gave a yield of 97,8%. Geometric standard deviation (sg) of colloidal particles amounted to 163.7 nm shaped poly-disperse.  Further study needs to be performed in due time in order to have Cr32PO4 colloids with suitable particle size.


keloid, chromic phosphate colloid, skin patch, condensation, oxidation-reduction reaction


B. Kichizo. The Preparation of Phosphorus-32 in a High Specific Activity Using the Szilard-Chalmers Effect * free paper the process for the preparation of phosphorus-, Radioisot. Prod. Lab. Japan At. Energy Res. Inst. Tokai-mura, Ibaraki, vol. 37, no. 12, pp. 1730–1733, 1964.

C. Jacobs, Melville L, Duarte. Radioactive Colloidal Chromic Phosphate To Control, in J A M A, 1958, vol. 166, no. 6, pp. 93–95.

G. Prabhakar, K. S. Mehra, and N. Ramamoorthy, Studies on the preparation and evaluation of colloidal chromic phosphate - 32 P for possible therapeutic use, IAEA-SR-209/32, no. Radiopharmaceuticals III, pp. 126–127, 1999.

IAEA-TECDOC-1228. Therapeutic applications of radiopharmaceuticals. Proceedings of an international seminar held in Hyderabad, India, 2001, no. June, pp. 18–22.

J. D. Lee et al. Radionuclide therapy of skin cancers and Bowen’s disease using a specially designed skin patch. J. Nucl. Med., vol. 38, no. 5, pp. 697–702, 1997.

L. J. Anghileri. Uptake of colloidal chromic radiophosphate (P-32) by bone and gonads. Radiology, vol. 85, no. 5, pp. 938–943, 1965.

M. J. Salgueiro et al. Design and bioevaluation of a32P-patch for brachytherapy of skin diseases. Appl. Radiat. Isot., vol. 66, no. 3, pp. 303–309, 2008.

M. J. Salgueiro et al. Radioactive treatment of a murine melanoma using a 32P-patch. Nucl. Med. Commun., vol. 30, no. 9, pp. 706–712, 2009.

M. Purba. Kimia Koloid. in, 2007, pp. 1–6.

M. Wells and S. M. MacBride. Radiation skin reactions. Support. care Radiotheraphy., pp. 135–159, 2003.

V. H. Witten, E. W. Brauer, V. Holmstrom, and R. Loevinger. Studies of Radioactive Phosphorus (P32) Applied to Human Skin. J. Invest. Dermatol., vol. 26, no. 6, pp. 437–447, 1956.

W. P. H. A. C. W. H. A. S. Van Den Brenk, K. H. Clarke. Studies Of The Effect Of A Colloidal Radioactive Chromic Phosphate (Cr32PO4) In Clinical And Experi- Mental Malignant Effusions. pp. 181–194, 1959., (diakses pada 21 Agustus 2018)

Y. Sunarya. Kimia Dasar 2. 2nd ed. Bandung: Yrama Widya, 2016.


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