Chitosan Concentration and Cross-linker Volume Effect on The Release Kinetic of Red Ginger Oleoresin Microcapsule in Simulated Intestinal Fluid (SIF) Medium

Jayanudin Jayanudin, Moh. Fahrurrozi, Sang Kompiang Wirawan, Rochmadi Rochmadi

Sari


Red ginger oleoresin contains components that can be used as antioxidants. Release kinetics studies are used to provide doses to achieve the desired drug concentration. The purpose of this study was to determine the release kinetics of red ginger oleoresin microcapsules based on changes in chitosan concentration and volume of cross-linker and determine the diffusion coefficient of red ginger oleoresin through microcapsule walls. Red ginger oleoresin microcapsules were prepared from a mixture of red ginger oleoresin in chitosan solution and stirred to form an emulsion. After that, it was added to corn oil and stirred again to form a second emulsion. Glutaraldehyde saturated toluene was added dropwise after finished added the 25% glutaraldehyde solution and remains stirred for 2 hours. Red ginger oleoresin microcapsules were separated and washed with petroleum ether and hexane, then dried in an oven. Microcapsules inserted in the release medium (simulated intestinal fluid) without enzymes, and then the samples were analyzed using a UV-vis spectrophotometer to determine the absorbance. The release kinetics models used were zero order, first order, Higuchi, Korsmeyer-Peppas, and Hixon-Crowell. The highest correlation coefficient (R2) was obtained from the Korsmeyer-Peppas release kinetics model, R2 = 0.73-0.85 with the value of n = 0.39-0.41. Based on the n value, the release mechanism of red ginger oleoresin microcapsules was Fickian diffusion. The diffusion coefficients obtained were 2,807 x 10-13 - 3,675 x 10-13 cm2 /sec.

Kata Kunci


kinetika release, kitosan, oleoresin jahe merah, stimulated intestinal fluid

Teks Lengkap:

PDF (English)

Referensi


Bellik Y, 2014. Total antioxidant activity and antimicrobial potency of the essential oil and oleoresin of Zingiber officinale Roscoe. Asian Pacific Journal of Tropical Disease, Vol. 4, No. 1: 40- 44.

Campos E, Coimbra P, Gil MH. 2013. An improved method for preparing glutaraldehyde cross-linked chitosan-poly(vinyl alcohol) microparticles. Polymer Bulletin, Vol. 70, No. 2: 549-561

Dash, Suvakanta, Padala Narasimha Murthy, Lilakanta Nath, and Prasanta Chowdhury. 2010. Kinetic Modeling on Drug Release from Controlled Drug Delivery Systems. Acta Poloniae Pharmaceutica, Vol. 67, No. 3: 217–23

Dozie-Nwachukwu SO, Danyuo Y, Obayemi JD, Odusanya OS, Malatesta K, Soboyejo WO. 2017. Extraction and encapsulation of prodigiosin in chitosan microspheres for targeted drug delivery. Materials Science and Engineering C. Vol. 71: 268-278.

Freitas MN dan Marchetti JM. 2005. Nimesulide PLA microspheres as a potential sustained release system for the treatment of inflammatory diseases. International Journal of Pharmaceutics. Vol. 295, No. 1-2: 201-211

Islam S., Rahman Bhuiyan, MA., Islam, MN., 2017. Chitin and Chitosan: Structure, Properties and Applications in Biomedical Engineering. Journal of Polymers and the Environment, Vol. 25, No. 3: 854-866

Jameela SR, Jayakrishnan A. 1995. Glutaraldehyde cross-linked chitosan microspheres as a long acting biodegradable drug delivery vehicle: studies on the in vitro release of mitoxantrone and in vivo degradation of microspheres in rat muscle. Biomaterials. Vol. 16, No. 10: 769-775

Jayanudin., Fahrurrozi M., Wirawan, SK., Rochmadi. 2018. Controlled Release Evaluation of Red Ginger Oleoresin Encapsulation using Simulated Gastric Fluid (SGF). Research Journal of Pharmacy and Technology. Vol. 11, No. 8: 3431-3436

Jayanudin., Fahrurrozi M., Wirawan, SK., Rochmadi. 2019. Mathematical modeling of the red ginger oleoresin release from chitosan-based microcapsules using emulsion crosslinking method. Engineering Science and Technology, an International Journal. Vol. 22, No. 2: 458-467

Manjanna KM, Shivakumar B, Kumar TMP. 2010. Microencapsulation: An Acclaimed Novel Drug-Delivery System for NSAIDs in Arthritis. Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol. 27, No. 6: 509-545

Nayak UY., Gopal S., Mutalik S., Ranjith AK., Reddy MS., Gupta P., Udupa N., 2009. Glutaraldehyde cross-linked chitosan microspheres for controlled delivery of Zidovudine. Journal of Microencapsulation. Vol. 26, No. 3: 214–222.

Oboh G., Ayodele JA., Adedayo OA, 2012. Antioxidant and inhibitory effect of red ginger (Zingiber officinale var. Rubra) and white ginger (Zingiber officinale Roscoe) on Fe2+ induced lipid peroxidation in rat brain in vitro. Experimental and Toxicologic Pathology, Vol. 64, No.1-2: 31– 36.

Ofokansi KC, Kenechukwu FC, Isah AB, Okigbo EL. 2013. Formulation and evaluation of glutaraldehyde-crosslinked chitosan microparticles for the delivery of ibuprofen. Tropical Journal of Pharmaceutical Research, Vol.12, No.1: 19-25

Patel KS, Patel MB. 2014. Preparation and evaluation of chitosan microspheres containing nicorandil. International Journal of Pharmaceutical Investigation. Vol. 4, No.1: 32-37.

Ravindran P N., Nirmal Babu K., Shiva KN, 2004. Botany and Crop Improvement of Ginger. In: Ravindran PN., Nirmal Babu K. Ginger: The Genus Zingiber. CRC PRESS. Boca Raton, Florida, pp. 15-86

Ritger PL, Peppas NA. 1987. A simple equation for description of solute release II. Fickian and anomalous release from swellable devices. Journal of Controlled Release. Vol. 5, No. 1: 37-42.

Shaikh J, Bhosale R, Singhal, R. 2006. Microencapsulation of black pepper oleoresin. Food Chemistry, Vol.94, No. 1: 105-110

Shoaib MH., Tazeen J., Merchant HA., Yousuf, RI. 2006. Evaluation of drug release kinetics from ibuprofen matrix tablets using HPMC. Pakistan Journal Of Pharmaceutical Sciences. Vol. 19, No.2: 119-124

Shruthi SB, Roy P, Sailaja RRN, Sengupta C. 2016. Encapsulation and release characteristics of Marigold oleoresin in chitosan grafted sodium acrylate-co-acrylamide. Advanced Materials Letters, Vol.7, No.10: 795-801

Siepmann J, Siepmann F. 2012. Modeling of diffusion controlled drug delivery. Journal of Control Release. Vol. 161, No.2: 351-362.

Thanoo, BC, Sunny MC, Jayakrishnan, A. 1992. Cross-linked Chitosan Microspheres: Preparation and Evaluation as a Matrix for the Controlled Release of Pharmaceuticals. Journal of Pharmacy and Pharmacology. Vol. 44, No.4: 283-286

Vaidya S, Bhosale R, Singhal RS. 2006. Microencapsulation of Cinnamon Oleoresin by Spray Drying Using Different Wall Materials. Drying Techology. Vol.24: 983–92.

Welty JR., Wicks CE., Wilson RE., Rorrer GL., 2007. Fundamentals of Momentum, Heat, and Mass Transfer. 5th edition. John Wiley & Sons, Inc. pp. 398-429.




DOI: https://doi.org/10.31315/e.v16i2.3088

Refbacks

  • Saat ini tidak ada refbacks.

##plugins.generic.alm.title##

##plugins.generic.alm.loading##

Metrics powered by PLOS ALM



Eksergi ISSN-p  1410-394X, ISSN-e 2460-8203 diterbitkan oleh Prodi Teknik Kimia Universitas Pembangunan Nasional "Veteran" Yogyakarta.

Sekretariat: Prodi Teknik Kimia UPN "Veteran" Yogyakarta Jl. SWK 104 (Lingkar Utara) Condong catur Sleman Yogyakarta 55283

Creative Commons License


Eksergi by http://jurnal.upnyk.ac.id/index.php/eksergi/index/ is licensed under a 
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Jumlah Pengunjung:

  web stats

View My Stats